Vitamin B15

Pangamic acid (vitamin B15, calcium pangamate) is an ester of dimethylglycine and gluconic acid, the so-called antitoxic factor, discovered in 1950 in Japan.

Biochemist T. Tomiyama first isolated the nutrient from bovine liver. A year later, the American scientist E. Krebs synthesized it from apricot seeds. Later, biochemists found that vitamin B15 is widely distributed in nature: it is found in plant bones. This led to the name of the substance, which arose as a result of a combination of two Greek words: "pan" - everywhere and "gamy" - seed.

The international name of the compound is Calcii pangamas.

Vitamin B15, like orotic acid (B13), belongs to the group of vitamin-like substances. These compounds are under detailed study.

Physiological role of vitamin B15 and indications for use

The pharmacological properties of the vitamin are determined by the methyl groups that are present in the pangamic acid molecule. In biochemical reactions, the nutrient acts as a donor of labile radicals. Easy waste of methyl particles potentiates the transmethylation reaction, which accelerates the activation of cellular respiration and redox processes in the body.

As a result, the vitamin acquires lipotropic, antioxidant and cytoprotective properties. Along with this, the nutrient improves the synthesis of creatine, nucleic acids, steroid hormones and compounds necessary for the full functioning of the body. The chemical formula of the compound is C10H19O8N2.

Pangamic acid is destroyed under the influence of UV rays, water. In pharmacies, the substance is sold in the form of a mineral supplement - a salt of the compound - calcium pangamate.

Vitamin B15 performs the following functions in the body:

  • eliminates cerebral hypoxia;
  • regulates lipid, protein and phosphorus-calcium metabolism;
  • stimulates the adrenal glands;
  • lowers cholesterol levels;
  • participates in the synthesis of DNA, RNA (the genetic material of cells);
  • increases the level of oxygen uptake by tissues;
  • protects liver cells from fatty degeneration;
  • accelerates recovery processes in muscles and tissues;
  • exhibits a moderate anabolic effect;
  • increases the lifespan of cells;
  • potentiates protein synthesis;
  • increases liver glycogen content;
  • prevents hangovers;
  • reduces addiction to alcohol;
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  • increases the concentration of creatine phosphate in muscle tissue;
  • prevents spasms of blood vessels and muscles;
  • helps lower blood pressure (as part of complex therapy);
  • stimulates the "correct" immune responses.

Vitamin B15, due to its extensive pharmacological properties, is used as part of the complex treatment of various diseases (see).

Instructions for use of pangamic acid

Indications for use of the compound:

  • vascular atherosclerosis;
  • emphysema (pathological expansion of the air space in the bronchi);
  • coronary insufficiency;
  • bronchial asthma;
  • obliterating endarteritis of the lower extremities;
  • pneumonia;
  • chronic hepatitis;
  • syphilitic aortitis;
  • pruritic dermatoses;
  • pneumosclerosis;
  • various lesions of cerebral arteries;
  • rheumatism;
  • cirrhosis of the liver;
  • intense exercise;
  • alcohol and drug intoxication.

Along with this, the vitamin is used to improve the tolerance of corticosteroids, sulfonamides and anti-tuberculosis drugs.

Contraindications: glaucoma, arterial hypertension (severe forms).

Today, scientists have not established the daily preventive norm of pangamic acid, which a person should consume daily. According to the literature, it is 1-2 milligrams per day. At the same time, for the treatment of certain diseases (rheumatism, vascular atherosclerosis, hepatitis, liver cirrhosis), the therapeutic dose of the drug increases to 50-200 milligrams.

Nutrient requirements also increase during intense exercise, as normal muscle function (muscle performance) requires an increased amount of oxygen in the tissues.

Sources of vitamin B15

Pharmaceutical companies today produce preparations containing a daily dose of calcium pangamate in large quantities.

When purchasing a supplement, remember that uncontrolled intake of a synthetic nutrient (overdose or ignoring contraindications) in 50% of cases harms human health.

Therefore, in the absence of prescriptions from the attending physician, it is advisable to obtain vitamin B15 from food.

Where is pangamic acid found (sources):

  1. Vegetable: brewer's yeast, sesame, poppy, wheat, brown rice, pumpkin, watermelon, melon, apricot, peach, sunflower seeds, almonds, beans, lentils, corn, peas, beans, walnuts, hazelnuts, pistachios, cereals (barley, wheat, rye, buckwheat), oatmeal, brazil nuts, eggs, rice bran, raspberries, apples, strawberries, pomegranates, plums.
  2. Animals: liver, kidneys.
  3. Synthesis in the body: some pangamic acid is produced by healthy intestinal microflora.

Knowing which foods contain a vitamin-like compound will help you properly balance your daily diet and get the right amount of the nutrient every day.

Signs of deficiency and excess of B15

Pangamic acid deficiency is rare, because, with a properly composed diet, the nutrient is supplied in sufficient quantities with food. However, with starvation, adherence to strict mono-diets or gastrointestinal diseases (the absorption of nutrients is disturbed), a B15-deficient state develops. In addition, a lack of pangamic acid often occurs against the background of diabetes mellitus.

Signs of vitamin deficiency in the human body:

  • irritability;
  • fatigue;
  • deterioration of the skin;
  • depression;
  • decreased performance;
  • tingling in limbs;
  • development of hypothyroidism;
  • abnormal heart rhythm;
  • Numbness of lips and/or fingertips.

If B15-hypovitaminosis is not eliminated in time, oxygen supply to the cells of organs and tissues decreases, which leads to disruption of the proper functioning of the brain and a decrease in the production of hormones produced by the thyroid gland. Along with this, the risk of developing pathologies of the heart, blood vessels, hypercholesterolemia and fatty degeneration of the liver increases.

Remember, even if indicated, do not self-medicate. It is important to select the daily rate of calcium pangamate only after consulting with your doctor. Otherwise, overdose symptoms may occur.

Signs of excess pangamic acid:

If B15 hypervitaminosis is detected, the drug should be discontinued immediately for safety reasons. If necessary, carry out symptomatic therapy (lavage of the stomach or intestines) and call a doctor.

Therapeutic Uses of Pangamic Acid

Pure vitamin B15 is extremely rare because it oxidizes rapidly when exposed to oxygen and ultraviolet radiation. Therefore, in medical practice, calcium or sodium salts of pangamic acid (calcium or sodium pangamate) are used, which stimulate the endocrine glands (pituitary and adrenal glands), activate transmethylation enzyme reactions, enhance the antioxidant defense of the body, increase the resistance of the body, in particular the myocardium, to oxygen " starvation." However, the clinical use of the vitamin compound for the treatment of diseases of the gastrointestinal tract, nervous, cardiovascular, musculoskeletal is still being studied.

Consider the cases in which calcium pangamate is used:

  1. Liver diseases. Vitamin B15, as part of complex therapy, helps to increase the concentration of albumin in the blood, reduces the number of globulins to normal, which improves the albumin-globulin ratio. Along with this, the nutrient increases the level of creatinine in the urine and blood, increases diuresis and improves the patient's well-being. Pangamate calcium is used for cirrhosis of the liver, chronic hepatitis, congestion on the background of alcoholism or circulatory disorders. The therapeutic dosage for intramuscular injection is 20 milligrams 2 times a day, for oral administration - 40 milligrams per day.
  2. Pathologies of the heart, blood vessels. Medicines containing pangamic acid are used to alleviate post-infarction and pre-infarction conditions. After the introduction of the compound, respiratory chain enzymes are activated, creatine biosynthesis is enhanced, which is accompanied by an improvement in myocardial trophism. Pangamic acid is used to treat atherosclerosis, hypertension, angina pectoris, coronary insufficiency (due to lipotropic and vasodilating properties). The daily dosage is selected by the doctor depending on the patient's condition and the severity of the pathology (from 30 to 100 milligrams per day).
  3. Neurological disorders. Pangamic acid is prescribed as part of the complex therapy of cognitive disorders, hysteria, seizures, epilepsy, hydrocephalus, cerebral palsy, bedwetting in children, depression and psycho-emotional overload. In the "presence" of calcium pangamate, an element of group B (happiness hormone) is synthesized - choline, which is involved in the myelination of nerve fibers and strengthening the membranes of brain cells. Given the fact that vitamin B15 improves tissue respiration and the transmission of impulses to neurons, it is successfully used in medical practice to combat sclerosis. Numerous studies by Dr. Benati testify to this. Thus, the scientist's experiment involved patients suffering from hemiplegia and other pathologies of the central nervous system. During the experiment, patients were administered 25 milligrams of calcium pangamate per day (intramuscularly). At the end of the experiment, Benati testified that the emotional status of the patients increased, the speech disorder decreased and the state of health improved.
  4. Diseases of the musculoskeletal system. Due to the fact that vitamin B15 reduces the irritating effect of salicylic sodium on the adrenal cortex and enhances the pharmacological properties of cortisone and acetylcholine, the compound is used as part of the complex treatment of rheumatoid arthritis.
  5. Elimination of intoxication. Given the fact that calcium pangamate has antitoxic properties, the drug is used for acute poisoning with alcohol, drugs, tetracycline antibiotics, chlorine-containing organic compounds. As a result of research, scientists noted that daily intake of vitamin B15 reduces cravings for the use of alcoholic beverages and drugs.

The therapeutic dose of calcium pangamate varies from 50 to 150 milligrams per day. The course of treatment is 18 - 40 days. If necessary, you can repeat the therapy after 3 months.

Vitamin B15 in sports

Pangamic acid is the most important vitamin for athletes, as it helps to more easily endure oxygen starvation of cells (hypoxia). Performing strength exercises is accompanied by a significant expenditure of energy, which is produced as a result of the oxidation of nutrients. During intensive training, the incoming oxygen is consumed instantly, as a result, its deficiency quickly occurs in the body of the athlete, slowing down the production of energy. As a result, the athlete, even with the correct distribution of the load, cannot lift the “necessary” weight or perform the required number of exercises designed to “work out” a certain muscle group.

An additional intake of vitamin B15 helps to eliminate oxygen starvation in cells and start the work of muscle tissue. The nutrient increases energy metabolism in the muscles (creatine phosphate and glycogen), resulting in increased endurance and performance.

In view of this, calcium pangamate is taken 2 weeks before the start of the competition, and the daily diet is enriched with products containing this vitamin.

For athletes, the daily norm of the substance is 100 - 150 milligrams. Duration of application - 3 weeks. After a 10-day break, vitamin intake is resumed.

In the presence of high blood pressure, the drug should be taken under the supervision of the attending physician.

Interactions with other substances

Vitamin B15 is a water-soluble compound that is easily destroyed by exposure to high temperatures and daylight. Short-term processing of products (within 5-7 minutes) on low heat under a tightly closed lid will help prevent nutrient loss.

Compatibility of vitamin B15 and other substances

  1. Calcium pangamate neutralizes the aggressive effects of toxic chlorine-containing substances that, when inhaled, affect the mucous membranes of internal organs.
  2. Vitamin B15 reduces the severity of side effects that occur after the use of tetracycline antibiotics, excessive doses of aspirin and sulfa drugs.
  3. Simultaneous intake of calcium ascorbate (organic vitamin C) and pangamic acid leads to an increase in the antioxidant properties of both substances.
  4. Vitamin B15 potentiates choline synthesis.
  5. Pangamic acid enhances the pharmacological properties of beta-carotene, tocopherol and cyanocobalamin.
  6. Vitamin-like compound improves the absorption of corticosteroid and anti-tuberculosis drugs.
  7. Caffeine, nicotine, alcohol reduce the concentration of the nutrient in the blood.
  8. Vitamin B17 enhances the oncoprotective properties of pangamic acid.

It is important to consider these interactions when compiling complex therapy for the treatment of diseases.

Vitamin B15 in oncology

Pangamic acid is an effective assistant in the fight against cancer. This is evidenced by the studies of Israeli scientists who have developed a scheme for transferring mutated cells to a dormant phase by “turning off” oxygen-free energy production in them. The experiment involved oncological patients who, according to the proposed schedule, took pangamic acid.

German biochemists have found that 4 times more energy is produced in a cancer cell due to the processes of glycolysis and glutaminolysis than in mitochondria. At the same time, the work of the last organoids practically stops, but they remain alive. Interestingly, the hydrolysis products of cancer cells suppress the functioning of mitochondria in healthy cells.

Since the concentration of glycolysis products is very high near the “foreign focus”, “killer cells” cannot approach it to carry out an attack, since energy production stops in them. This phenomenon explains the reason for the inaction of the immune system on the growth of tumor tissue.

Israeli scientists found that taking calcium pangamate, due to improved oxygen uptake by tissues, leads to the activation of mitochondria, as a result of which glutaminolysis and glycolysis in the pathological focus are suppressed. Saturated with pangamic acid, foreign cells stop producing toxic substances, which helps natural killers attack the cancerous tumor without hindrance. At the same time, metastases are suppressed, and local inflammation stops growth for the duration of immunotherapy.

Due to the cessation of the production of toxic substances, when taking 100 milligrams of vitamin B15, the patient's pain syndrome disappears for 2-3 hours.

Thus, calcium pangamate puts malignant cells into a “sleeping” state. Along with this, vitamin B17 is used, which enhances the pharmacological properties of pangamic acid. Against the background of immunotherapy, it is advisable to use foods rich in these nutrients.

Conclusion

Pangamic acid is a valuable vitamin for the human body, as it participates in the regulation of metabolism of proteins and fats, prolongs the life cycle of cells, helps synthesize enzymes and hormones, accelerates the recovery processes in tissues, especially after intense training. At the same time, remember that uncontrolled intake, accompanied by an excess of a substance in the body, leads to the development of side effects, which is harmful to human health.

Since the nutrient is present in almost every plant, it is preferable to consume it naturally in food. At the same time, it is permissible to use biologically active additives of the substance in a dosage of a smaller daily one.

Daily intake of foods rich in vitamin B15 is the “ideal” prevention of fatty liver, hypercholesterolemia and oxygen starvation of internal organs.