Vitamin H1/B10

Para-aminobenzoic acid or vitamin B10, H1, PABA, PABA is a vitamin-like compound, a derivative of benzoic acid, which has a powerful antioxidant effect on the human body.

The name of the substance comes from two words - "pan" - everywhere, "gami" - seed, which indicates the wide distribution of the nutrient in nature, for example, in plant seeds.

The compound stimulates the growth of lactobacteria and bifidobacteria, has antiviral properties, and is used to make novocaine. Bacterial vitamin H1 protects the skin from the harmful effects of sunlight, improves the condition of the hair, so manufacturers add the product to the composition of conditioners, body creams, shampoos, ointments against burns, suntan lotions, and conditioners.

4-Aminobenzoic acid is a white powder, has a crystalline structure, is readily soluble in alcohol, ether, bad - in the water. PABA is resistant to high temperatures, is not destroyed by boiling (melting point reaches 187 degrees), and is sensitive to light.

The structural formula of the compound is C7H7NO2.

Importance and need for vitamin B10

Consider why the body needs H1.

  1. Prevents premature aging, wrinkles.
  2. Participates in the metabolism of proteins (DNA and RNA), the synthesis of pyrimidines, purines, the production of melanin.
  3. Promotes the growth of muscle tissue.
  4. Participates in normal digestion.
  5. Strengthens the immune system, stimulates the synthesis of interferon, increasing the body's resistance to infectious agents.
  6. Protects the liver from cirrhosis.
  7. Needed to replace cell structures, tissues, maintain men's health (prevents the appearance of Peyronie's disease).
  8. Normalizes fat metabolism, the content of cholesterol in the blood, preventing atherosclerosis.
  9. Prevents the development of a hangover.
  10. Improves hematopoiesis (supplies blood with oxygen, participates in the production of red blood cells), reduces the risk of anemia, blood clots, strokes.
  11. Protects the skin from UV rays, increases its tone and elasticity, eliminates hyperpigmentation, ensures the formation of an even tan.
  12. Prevents hair loss, maintains their natural color, prevents early graying.
  13. Improves tissue repair after injuries, growth in children, adolescents, production of women's milk during lactation.
  14. Stimulates the reproduction of beneficial microflora in the intestines.

In addition, para-aminobenzoic acid increases the effectiveness of B vitamins (B5, B9) and C.

Instructions for use

Given the fact that PABA has not been studied much to date, according to the literature, a person's need for a compound is 100 milligrams per day. For medicinal purposes, the dosage of vitamin H1 is determined by the attending physician, depending on the type of therapy and the nature of the disease.

Vitamin supplements are recommended to be taken after a meal with 100 milliliters of non-carbonated water.

Causes and signs of PABA deficiency and excess

Most often, PABA deficiency occurs against the background of long-term use of antibiotics, analgesics, antipyretics, estrogen-containing drugs or sulfonamides. In addition, improper storage and preparation of foods rich in vitamin H1 leads to the loss of a useful nutrient. Para-aminobenzoic acid is destroyed under prolonged influence of high temperatures (over 20 minutes), from the action of alcohol.

Signs of paraaminobenzoic acid deficiency:

  • irritability;
  • weakness ;
  • ​​
  • headaches;
  • hormonal disorders, gastrointestinal tract, nervous system;
  • headaches;
  • developmental delay, growth;
  • hair loss, brittle hair (baldness);
  • depression ;
  • frequent sunburn;
  • fatigue;
  • the appearance of skin rashes, age spots, dermatological diseases;
  • decreased lactation in lactating women.

Characteristic signs of excess vitamin H1 in the body:

  • nausea;
  • vomiting;
  • suppression of the activity of the thyroid gland.

An excess of para-aminobenzoic acid in the body does not pose a threat to human life. Symptoms of an overdose go away after a decrease in the amount of the substance taken.

Indications for use and contraindications

Vitamin B10 is used in medicine to eliminate the following disease conditions:

  • neuro-emotional overstrain;
  • arthritis and arthrosis;
  • vitiligo disease;
  • alopecia;
  • physical and mental overwork;
  • anemia (folate deficiency);
  • Dupuytren's contractures;
  • stress;
  • diseases of the skin, in particular pruritic dermatoses;
  • Peyronie's disease;
  • scleroderma;
  • delays in development, growth;
  • menopause;
  • brittle nails;
  • ultraviolet burns;
  • atherosclerosis;
  • rheumatism;
  • emphysema;
  • pneumosclerosis;
  • bronchial asthma;
  • chronic coronary insufficiency;
  • hepatitis;
  • cerebral vascular sclerosis;
  • cirrhosis of the liver at the initial stage;
  • chronic alcohol intoxication.

In addition, para-aminobenzoic acid is used to strengthen hair, better tolerance of corticosteroids, sulfonamides, anti-tuberculosis drugs.

Contraindications for taking PABA include:

  • hypervitaminosis;
  • thyroid disorders;
  • drug sensitivity.

In 90% of cases, vitamin B10 is well absorbed by the body, with sufficient intake of folic acid, without causing adverse reactions.

In a healthy person (without problems with the gastrointestinal tract), with a balanced diet, compound H1 is synthesized by the intestinal microflora.

PABA absorption occurs in the upper intestine. At the same time, part of the compound is used by the microflora of the large intestine to synthesize vitamin B9. The concentration of para-aminobenzoic acid in human blood is from 2 to 70 micrograms per deciliter.

The compound is excreted in the urine in the acetylated form. The level of PABA in the body depends on the state of human health: with gastric ulcer, chronic hepatitis, cholecystitis, Botkin's disease, it decreases, and if there are problems with the cardiovascular system, it increases. 250 micrograms of the nutrient is excreted in the feces.

Sources of para-aminobenzoic acid

Vitamin B10 was first isolated from yeast and subsequently found in foods. At the same time, food dyes, refined sugar reduce the production of PABA by the intestinal microflora.

Consider where the substance is contained and in what quantity (data are presented at the rate of x microgram of nutrient per 100 grams of product):

  • dry brewer's yeast - 5.7;
  • liver (beef, pork) – 0.25;
  • kidneys – 0.18;
  • heart, brain - 0.135;
  • mushrooms – 0.13;
  • spinach - 0.06;
  • wheat – 0.06;
  • chicken eggs - 0.04;
  • potatoes – 0.036;
  • carrots – 0.022;
  • white cabbage – 0.02;
  • cow's milk - 0.01.

Food sources containing low amounts of vitamin H1 (up to 0.01 micrograms per 100 grams of food):

  • rice bran;
  • sunflower seeds;
  • parsley;
  • lemon balm;
  • fermented milk products (kefir, cottage cheese, cheese);
  • nuts (cashews, hazelnuts, pistachios, walnuts);
  • oatmeal;
  • fish;
  • molasses;
  • pumpkin seeds, sesame seeds;
  • apricot kernels.

In the absence of diseases of the digestive tract and a balanced diet, the constant presence in the daily menu of plant / animal products rich in para-aminobenzoic acid eliminates the need for the body to additionally take a vitamin compound with drugs, supplements.

However, the presence of diseases of the liver, stomach impair the absorption of nutrients from the gastrointestinal tract and are a "signal" to take synthetic B10.

Interaction with other substances

In medical practice, vitamin H1 has not found wide application, despite the fact that the compound was used experimentally and in the clinic for prophylactic, therapeutic purpose to eliminate a number of skin diseases. The use of PABA in large doses (5 grams per day) in the complex therapy of typhus has demonstrated the high efficiency of the drug. In the treatment of rickettsiosis with para-aminobenzoic acid, relative to conventional therapeutic measures, the mortality rate from this disease decreased by 3 times, and the recovery process also accelerated.

Vitamin B10 at a dose of 0.1 to 0.5 grams is used as part of complex therapy for the treatment of hypertension and atherosclerosis. After a course of therapy of 20 days, the patients' working capacity increased, their general well-being improved, protein and lipid metabolism normalized.

Consider how para-aminobenzoic acid affects the absorption of other substances and vice versa.

  1. Alcohol, penicillin, sulfa drugs, sugar destroy vitamin B10 in the human body.
  2. The combined action of folic acid, para-aminobenzoic acid and pyridoxine inhibits graying of hair.
  3. B10 reduces the effectiveness of thyroid hormones, the effects of adrenaline.
  4. Para-aminobenzoic acid reduces the side effects of excess aspirin in the body.
  5. Compound H1 increases the effectiveness of vitamins C, B5, B9.
  6. Vitamins A, E increase the effect of the nutrient on metabolism.

Vitamin H1 is available in tablets, drops, powders, capsules, vials and ampoules (as a solution for injection and eye drops). The most popular PABA drug is RAVA, which is produced by the American corporation Now Foods. In addition, para-aminobenzoic acid is part of multivitamin complexes - Multivita, Vitrum.